Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8061563 | 1.00 | LMNA (0.51) | LMNAHTTTSHRALOX12NPSR1 | |
| SCHEMBL4541025 | 0.95 | MEN1 (0.50) | LMNAHTTTSHRALOX12NPSR1 | |
| SCHEMBL4541776 | 0.94 | LMNA (0.55) | LMNAHTTTSHRALOX12NPSR1 | |
| SCHEMBL8064991 | 0.90 | ALDH1A1 (0.49) | LMNAHTTTSHRALOX12NPSR1 | |
| SCHEMBL4542554 | 0.90 | DRD2 (0.51) | LMNAHTTTSHRALOX12NPSR1 | |
| SCHEMBL4541335 | 0.89 | CYP3A4 (0.51) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4531159 | 0.89 | ALDH1A1 (0.51) | LMNAHTTTSHRALOX12NPSR1 | |
| SCHEMBL8066749 | 0.89 | CYP3A4 (0.51) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4532816 | 0.89 | TP53 (0.48) | LMNATSHRALOX12ALDH1A1POLB | |
| SCHEMBL4542831 | 0.89 | ALDH1A1 (0.53) | LMNAALDH1A1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |