Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.54 |
| ▸ | BRD2 | P25440 | 4/20 | 0.54 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.49 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 10/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 9/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4534756 | 0.90 | RAB9A (0.49) | EPHX1EPHX2 | |
| SCHEMBL4542837 | 0.88 | RAB9A (0.53) | EPHX1EPHX2 | |
| SCHEMBL4539998 | 0.88 | LMNA (0.55) | EPHX1EPHX2 | |
| SCHEMBL4539776 | 0.87 | BRD4 (0.53) | BRD4BRD2BRD3BRDTEPHX1 | |
| SCHEMBL8069510 | 0.87 | BRD4 (0.53) | BRD4BRD2BRD3BRDTEPHX2 | |
| SCHEMBL4542461 | 0.87 | RAB9A (0.50) | EPHX1EPHX2 | |
| SCHEMBL8069502 | 0.87 | RAB9A (0.50) | EPHX1EPHX2 | |
| SCHEMBL8064960 | 0.86 | EPHX2 (0.50) | BRD4BRD2EPHX1EPHX2 | |
| SCHEMBL4537185 | 0.85 | RAB9A (0.56) | EPHX1EPHX2 | |
| SCHEMBL4537316 | 0.85 | LMNA (0.56) | EPHX1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |