Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 2/20 | 0.51 |
| ▸ | MMP3 | P08254 | 2/20 | 0.51 |
| ▸ | MMP7 | P09237 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8064929 | 0.97 | RAB9A (0.59) | RAB9APAX8ALDH1A1LMNANPSR1 | |
| SCHEMBL4542837 | 0.90 | RAB9A (0.53) | RAB9APAX8LMNAEPHX2EPHX1 | |
| SCHEMBL4534756 | 0.88 | RAB9A (0.49) | RAB9ANPC1EPHX2EPHX1 | |
| SCHEMBL4539998 | 0.88 | LMNA (0.55) | PAX8LMNANPSR1EPHX2EPHX1 | |
| SCHEMBL4538117 | 0.87 | FKBP1A (0.48) | RAB9APAX8ALDH1A1LMNANPSR1 | |
| SCHEMBL4535199 | 0.87 | MMP1 (0.53) | RAB9APAX8MMP1MMP3MMP7 | |
| SCHEMBL8062528 | 0.86 | RAB9A (0.50) | RAB9APAX8MMP1MMP3MMP7 | |
| SCHEMBL4535376 | 0.85 | BRD4 (0.54) | EPHX2EPHX1 | |
| SCHEMBL8069502 | 0.85 | RAB9A (0.50) | RAB9ANPC1EPHX2EPHX1 | |
| SCHEMBL4542461 | 0.85 | RAB9A (0.50) | RAB9ANPC1EPHX2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |