Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CCR3 | P51677 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542461 | 1.00 | RAB9A (0.50) | RAB9ANPC1CCR3EPHX2MEN1 | |
| SCHEMBL4534756 | 0.97 | RAB9A (0.49) | RAB9ANPC1CCR3EPHX2MEN1 | |
| SCHEMBL4537316 | 0.90 | LMNA (0.56) | RAB9AEPHX2EPHX1 | |
| SCHEMBL4542345 | 0.90 | EPHX2 (0.56) | RAB9AEPHX2EPHX1 | |
| SCHEMBL8064929 | 0.87 | RAB9A (0.59) | RAB9ANPC1EPHX2EPHX1 | |
| SCHEMBL4542837 | 0.87 | RAB9A (0.53) | RAB9AEPHX2EPHX1 | |
| SCHEMBL4539998 | 0.87 | LMNA (0.55) | EPHX2EPHX1 | |
| SCHEMBL4535376 | 0.87 | BRD4 (0.54) | EPHX2EPHX1 | |
| SCHEMBL4535339 | 0.86 | ATM (0.47) | RAB9AATM | |
| SCHEMBL4542153 | 0.86 | ALDH1A1 (0.47) | RAB9ANPC1EPHX1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |