Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NR1D1 | P20393 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.38 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.38 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | NR1D2 | Q14995 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537103 | 0.81 | KDM4E (0.54) | LMNAHTTPKMKMT2AMAPT | |
| SCHEMBL4539333 | 0.80 | KMT2A (0.56) | LMNABRD4EPHX2KMT2AMEN1 | |
| SCHEMBL4537217 | 0.78 | BRD4 (0.55) | LMNAHTTTDP1BRD4MAPT | |
| SCHEMBL4535726 | 0.77 | ELOVL6 (0.41) | LMNAMAPK1EPHX2CTSDBACE1 | |
| SCHEMBL4542442 | 0.76 | BRD4 (0.44) | LMNATPSAB1TDP1BRD4MAPK1 | |
| SCHEMBL4541042 | 0.75 | FAAH (0.53) | BRD4EPHX2KMT2AMAPTMEN1 | |
| SCHEMBL4537350 | 0.75 | EPHX2 (0.43) | LMNAHTTEPHX2 | |
| SCHEMBL4542312 | 0.74 | EPHX2 (0.61) | EPHX2 | |
| SCHEMBL4535122 | 0.74 | KMT2A (0.60) | BRD4KMT2AMEN1 | |
| SCHEMBL4535568 | 0.74 | EPHX2 (0.64) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |