Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4536856 | 0.95 | KMT2A (0.44) | KMT2AMEN1EPHX1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4537222 | 0.94 | KMT2A (0.51) | KMT2AMEN1EPHX1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8066091 | 0.94 | KMT2A (0.51) | KMT2AMEN1EPHX1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4541178 | 0.87 | EPHX1 (0.50) | KMT2AEPHX1SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL4539129 | 0.85 | EPHX2 (0.52) | KMT2AMEN1EPHX1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4535493 | 0.85 | HDAC3 (0.52) | KMT2AEPHX1SMN1; SMN2LMNARAB9A | |
| SCHEMBL8070996 | 0.85 | HDAC3 (0.52) | KMT2AEPHX1SMN1; SMN2LMNARAB9A | |
| SCHEMBL4542516 | 0.83 | LMNA (0.49) | KMT2AMEN1EPHX1ALDH1A1LMNA | |
| SCHEMBL4532833 | 0.83 | KMT2A (0.53) | KMT2AMEN1EPHX1ALDH1A1LMNA | |
| SCHEMBL4540431 | 0.83 | NPC1 (0.55) | KMT2AEPHX1SMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |