Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537427 | 0.95 | SMN1; SMN2 (0.52) | NPC1RAB9AKMT2ASMN1; SMN2EPHX1 | |
| SCHEMBL4543052 | 0.94 | NPC1 (0.48) | NPC1RAB9AKMT2ASMN1; SMN2EPHX1 | |
| SCHEMBL4542094 | 0.93 | NPC1 (0.57) | NPC1RAB9AKMT2ASMN1; SMN2EPHX1 | |
| SCHEMBL4539274 | 0.89 | CYP3A4 (0.51) | NPC1KMT2AEPHX1ALDH1A1LMNA | |
| SCHEMBL4536776 | 0.89 | LMNA (0.62) | NPC1RAB9AKMT2ASMN1; SMN2EPHX1 | |
| SCHEMBL4535944 | 0.89 | EPHX1 (0.52) | RAB9AEPHX1ALDH1A1LMNATSHR | |
| SCHEMBL4537257 | 0.88 | LMNA (0.51) | NPC1RAB9AKMT2ASMN1; SMN2EPHX1 | |
| SCHEMBL4539985 | 0.88 | TSHR (0.50) | NPC1RAB9AKMT2ASMN1; SMN2EPHX1 | |
| SCHEMBL4539809 | 0.88 | HSD11B1 (0.52) | NPC1RAB9AKMT2ASMN1; SMN2EPHX1 | |
| SCHEMBL8053303 | 0.88 | HSD11B1 (0.52) | NPC1RAB9AKMT2ASMN1; SMN2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |