Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537257 | 0.94 | LMNA (0.51) | LMNAUSP2EPHX1EPHX2KMT2A | |
| SCHEMBL4537048 | 0.89 | LMNA (0.47) | LMNAUSP2EPHX1EPHX2KMT2A | |
| SCHEMBL4542374 | 0.88 | HSD11B1 (0.53) | LMNAUSP2EPHX1EPHX2KMT2A | |
| SCHEMBL4542983 | 0.87 | EPHX1 (0.57) | LMNAUSP2EPHX1EPHX2KMT2A | |
| SCHEMBL4542094 | 0.87 | NPC1 (0.57) | LMNAUSP2EPHX1EPHX2KMT2A | |
| SCHEMBL4541867 | 0.86 | CNR1 (0.51) | LMNAUSP2EPHX1EPHX2KMT2A | |
| SCHEMBL4535231 | 0.83 | HTR7 (0.52) | LMNAUSP2EPHX1EPHX2KMT2A | |
| SCHEMBL4542494 | 0.83 | HTR7 (0.52) | LMNAUSP2EPHX1EPHX2KMT2A | |
| SCHEMBL4537661 | 0.82 | HTR1A (0.48) | LMNAUSP2EPHX1EPHX2KMT2A | |
| SCHEMBL4537521 | 0.82 | LMNA (0.54) | LMNAUSP2EPHX1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |