Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535235 | 0.97 | RAB9A (0.47) | BDKRB1RAB9AHCRTR1HCRTR2 | |
| SCHEMBL4541043 | 0.90 | ITGB1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4530967 | 0.90 | HTR7 (0.48) | RAB9A | |
| SCHEMBL8062041 | 0.89 | RAB9A (0.47) | RAB9AALDH1A1 | |
| SCHEMBL4536848 | 0.89 | HTR1A (0.48) | RAB9A | |
| SCHEMBL4535933 | 0.88 | PSEN1 (0.56) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4537565 | 0.88 | RAB9A (0.51) | RAB9AALDH1A1 | |
| SCHEMBL4542139 | 0.88 | PAX8 (0.45) | BDKRB1RAB9AHCRTR1HCRTR2 | |
| SCHEMBL4542596 | 0.87 | MAPT (0.44) | RAB9AHCRTR1HCRTR2MEN1ALDH1A1 | |
| SCHEMBL4539341 | 0.87 | EPHX1 (0.48) | BDKRB1RAB9AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |