Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542597 | 0.90 | MAPT (0.45) | TSHRRAB9AHTR7PSEN1PSEN2 | |
| SCHEMBL4535937 | 0.87 | PSEN1 (0.58) | RAB9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4531295 | 0.86 | RAB9A (0.43) | TSHRRAB9APSEN1PSEN2APH1B | |
| SCHEMBL4541108 | 0.86 | NPBWR1 (0.52) | TSHRRAB9AHTR7PSEN1PSEN2 | |
| SCHEMBL4537004 | 0.86 | RAB9A (0.49) | TSHRRAB9ADRD2DRD3PAX8 | |
| SCHEMBL4538143 | 0.85 | RAB9A (0.50) | RAB9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4541044 | 0.85 | CNR1 (0.45) | RAB9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4534376 | 0.85 | PSEN1 (0.40) | RAB9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4530970 | 0.84 | HTR7 (0.52) | RAB9AHTR7HTR1ADRD2HTR1D | |
| SCHEMBL4538792 | 0.84 | PSEN1 (0.53) | RAB9APSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |