Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20600392 | 0.70 | NPC1 (0.44) | KDM4EPKMMAPK1MEN1KMT2A | |
| SCHEMBL316035 | 0.66 | KDM4E (0.75) | KDM4EPKMMAPK1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL19118816 | 0.65 | KDM4E (0.73) | KDM4EPKMMAPK1MEN1KMT2A | |
| SCHEMBL6312708 | 0.65 | PKM (0.71) | KDM4EPKMMAPK1MEN1KMT2A | |
| SCHEMBL3748827 | 0.65 | PKM (0.54) | KDM4EPKMMAPK1MEN1KMT2A | |
| SCHEMBL4775643 | 0.65 | KDM4E (0.64) | KDM4EPKMMAPK1MEN1KMT2A | |
| SCHEMBL352388 | 0.64 | ALDH1A1 (0.46) | KDM4EPKMTDP1ALDH1A1HCAR2 | |
| SCHEMBL2168269 | 0.64 | CA12 (0.42) | KDM4EPKMTDP1ALDH1A1HCAR2 | |
| SCHEMBL29415465 | 0.64 | ALDH1A1 (0.46) | KDM4EPKMTDP1ALDH1A1HCAR2 | |
| SCHEMBL29248881 | 0.62 | LMNA (0.46) | TDP1LMNAALDH1A1APOBEC3ACTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029572-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007143597-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2007-12-13 | — | — | WO | disclosed |