Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 13/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | BRD2 | P25440 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535072 | 0.97 | BDKRB1 (0.56) | BDKRB1POLBEPHX2CNR1KMT2A | |
| SCHEMBL4541345 | 0.88 | POLB (0.44) | BDKRB1POLBKMT2ANPC1RAB9A | |
| SCHEMBL8064960 | 0.88 | EPHX2 (0.50) | BDKRB1POLBEPHX2BRD4BRD2 | |
| SCHEMBL4539776 | 0.86 | BRD4 (0.53) | BDKRB1BRD4BRD2 | |
| SCHEMBL4535231 | 0.86 | HTR7 (0.52) | BDKRB1EPHX2KMT2ANPC1RAB9A | |
| SCHEMBL4536998 | 0.86 | BDKRB1 (0.49) | BDKRB1KMT2AHCRTR1HCRTR2NPC1 | |
| SCHEMBL4542494 | 0.86 | HTR7 (0.52) | BDKRB1EPHX2KMT2ANPC1RAB9A | |
| SCHEMBL4542819 | 0.85 | RAB9A (0.54) | EPHX2KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4541867 | 0.85 | CNR1 (0.51) | EPHX2CNR1KMT2ASMN1; SMN2 | |
| SCHEMBL4538146 | 0.85 | CNR1 (0.47) | POLBEPHX2CNR1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |