Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539565 | 0.87 | EPHX2 (0.48) | ALDH1A1L3MBTL1MAPTKDM4EMCL1 | |
| SCHEMBL4537189 | 0.85 | FAAH (0.49) | ALDH1A1L3MBTL1 | |
| SCHEMBL4537541 | 0.85 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1KMT2AMEN1MAPK1 | |
| SCHEMBL4542230 | 0.85 | CYP19A1 (0.54) | ALDH1A1L3MBTL1MAPTKDM4EMCL1 | |
| SCHEMBL4535742 | 0.83 | NPC1 (0.52) | ALDH1A1L3MBTL1MAPTKDM4EMCL1 | |
| SCHEMBL4539885 | 0.82 | FAAH (0.45) | ALDH1A1L3MBTL1POLB | |
| SCHEMBL4539993 | 0.81 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1MAPTKDM4EMCL1 | |
| SCHEMBL4533514 | 0.81 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1KMT2AMEN1BRD4 | |
| SCHEMBL4535453 | 0.80 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1MAPTKDM4EKMT2A | |
| SCHEMBL4537967 | 0.79 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1KMT2ATSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |