Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539565 | 0.88 | EPHX2 (0.48) | ALDH1A1EPHX2L3MBTL1KMT2AMEN1 | |
| SCHEMBL4537189 | 0.88 | FAAH (0.49) | ALDH1A1EPHX2L3MBTL1HTR2AHTR2C | |
| SCHEMBL4537013 | 0.85 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1KMT2APOLBMEN1 | |
| SCHEMBL4539885 | 0.84 | FAAH (0.45) | ALDH1A1EPHX2L3MBTL1POLB | |
| SCHEMBL4535924 | 0.84 | ALDH1A1 (0.59) | ALDH1A1EPHX2L3MBTL1KMT2APOLB | |
| SCHEMBL4537192 | 0.82 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1PKMKMT2APOLB | |
| SCHEMBL4535453 | 0.82 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1KMT2APOLBGAA | |
| SCHEMBL4533514 | 0.82 | ALDH1A1 (0.53) | ALDH1A1EPHX2L3MBTL1KMT2AMEN1 | |
| SCHEMBL4535939 | 0.80 | USP30 (0.48) | ALDH1A1EPHX2L3MBTL1KMT2AMEN1 | |
| SCHEMBL4542924 | 0.80 | CYP3A4 (0.59) | ALDH1A1L3MBTL1KMT2AGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |