SCHEMBL4537189

SCHEMBL4537189

O=C(NCC1CCN(S(=O)(=O)c2ccccc2Cl)C1)N[C]1CCCCCCC1.[CH2].[CH2]

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FAAH O00519 5/20 0.49
HDAC3 O15379 1/20 0.48
HDAC4 P56524 1/20 0.48
HDAC1 Q13547 1/20 0.48
HDAC7 Q8WUI4 1/20 0.48
HDAC2 Q92769 1/20 0.48
HDAC10 Q969S8 1/20 0.48
HDAC11 Q96DB2 1/20 0.48
HDAC8 Q9BY41 1/20 0.48
HDAC6 Q9UBN7 1/20 0.48
HDAC9 Q9UKV0 1/20 0.48
HDAC5 Q9UQL6 1/20 0.48
ALDH1A1 P00352 4/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
EPHX2 P34913 3/20 0.48
TP53 P04637 1/20 0.43
HSD11B1 P28845 1/20 0.41
HTR2A P28223 1/20 0.40
HTR2C P28335 1/20 0.40
ACLY P53396 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4539885 0.96 FAAH (0.45) FAAHHDAC3HDAC4HDAC1HDAC7
SCHEMBL4535939 0.88 USP30 (0.48) ALDH1A1L3MBTL1EPHX2TP53ACLY
SCHEMBL4537541 0.88 ALDH1A1 (0.52) ALDH1A1L3MBTL1EPHX2HTR2AHTR2C
SCHEMBL4539565 0.88 EPHX2 (0.48) FAAHALDH1A1L3MBTL1EPHX2TP53
SCHEMBL4537246 0.87 HSD11B1 (0.56) EPHX2TP53HSD11B1
SCHEMBL4539756 0.86 HDAC3 (0.50) FAAHHDAC3HDAC4HDAC1HDAC7
SCHEMBL4537013 0.85 ALDH1A1 (0.44) ALDH1A1L3MBTL1
SCHEMBL4542938 0.85 HSD11B1 (0.51) FAAHALDH1A1L3MBTL1EPHX2TP53
SCHEMBL4535088 0.85 USP30 (0.47) ALDH1A1L3MBTL1EPHX2TP53
SCHEMBL4539044 0.84 ALDH1A1 (0.50) ALDH1A1L3MBTL1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009070497-A1 SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE SMITHKLINE BEECHAM CORPORATION (US) 2009-06-04 WO claimed
WO-2009070497-A1 SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE SMITHKLINE BEECHAM CORPORATION (US) 2009-06-04 WO disclosed