Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060983 | 1.00 | P2RX7 (0.47) | P2RX7DRD2DRD4EPHX2TRPV4 | |
| SCHEMBL4537384 | 0.95 | P2RX7 (0.45) | P2RX7DRD2DRD4EPHX2TRPV4 | |
| SCHEMBL4537312 | 0.90 | P2RX7 (0.43) | P2RX7DRD2DRD4MEN1KMT2A | |
| SCHEMBL4542824 | 0.87 | HDAC3 (0.52) | P2RX7EPHX2ALDH1A1 | |
| SCHEMBL4541776 | 0.86 | LMNA (0.55) | DRD2DRD4MEN1KMT2AKDM4E | |
| SCHEMBL8062169 | 0.84 | FBP1 (0.50) | MEN1KMT2AALDH1A1 | |
| SCHEMBL4542443 | 0.84 | FBP1 (0.50) | MEN1KMT2AALDH1A1 | |
| SCHEMBL4530293 | 0.84 | P2RX7 (0.44) | P2RX7DRD2DRD4 | |
| SCHEMBL4537224 | 0.83 | P2RX7 (0.43) | P2RX7DRD2DRD4 | |
| SCHEMBL4539753 | 0.82 | HDAC3 (0.49) | P2RX7EPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |