Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537312 | 0.95 | P2RX7 (0.43) | P2RX7DRD2DRD4USP30ALDH1A1 | |
| SCHEMBL4537036 | 0.95 | P2RX7 (0.47) | P2RX7DRD2DRD4EPHX2TRPV4 | |
| SCHEMBL8060983 | 0.95 | P2RX7 (0.47) | P2RX7DRD2DRD4EPHX2TRPV4 | |
| SCHEMBL4539753 | 0.88 | HDAC3 (0.49) | P2RX7ACLYEPHX2ALDH1A1 | |
| SCHEMBL4535935 | 0.87 | EPHX2 (0.52) | EPHX2 | |
| SCHEMBL8061563 | 0.86 | LMNA (0.51) | DRD2DRD4EPHX2ALDH1A1SLC13A5 | |
| SCHEMBL4535269 | 0.86 | LMNA (0.51) | DRD2DRD4EPHX2ALDH1A1SLC13A5 | |
| SCHEMBL4535853 | 0.84 | FBP1 (0.46) | ALDH1A1SLC13A5MEN1KMT2A | |
| SCHEMBL4538127 | 0.83 | CCR1 (0.46) | P2RX7EPHX2 | |
| SCHEMBL8049830 | 0.83 | HSD11B1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |