Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4292571 | 0.98 | ALDH1A1 (0.39) | ALDH1A1POLBSMN1; SMN2HPGDPKM | |
| SCHEMBL4299855 | 0.87 | SIGMAR1 (0.42) | ALDH1A1POLBCHRM2CHRM3TSHR | |
| SCHEMBL4537415 | 0.78 | ALDH1A1 (0.36) | ALDH1A1POLBSMN1; SMN2HPGDCHRM2 | |
| SCHEMBL8544469 | 0.77 | ALDH1A1 (0.45) | ALDH1A1POLBSMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL4292570 | 0.77 | ALDH1A1 (0.38) | ALDH1A1POLBSMN1; SMN2HPGDCHRM2 | |
| SCHEMBL4142245 | 0.75 | ALDH1A1 (0.47) | ALDH1A1POLBSMN1; SMN2HPGDLMNA | |
| SCHEMBL379431 | 0.75 | SIGMAR1 (0.51) | ALDH1A1POLBSMN1; SMN2CHRM2CHRM3 | |
| SCHEMBL28026626 | 0.74 | ALDH1A1 (0.42) | ALDH1A1POLBSMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL6678148 | 0.73 | NPSR1 (0.50) | ALDH1A1POLBSMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL18428973 | 0.72 | ALDH1A1 (0.45) | ALDH1A1POLBSMN1; SMN2HPGDPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286779-A1 | PYRAZOLOPYRIMIDINES AS LIPID KINASE INHIBITORS | NOVARTIS AG | 2009-11-19 | — | — | US | claimed |
| US-20090286779-A1 | PYRAZOLOPYRIMIDINES AS LIPID KINASE INHIBITORS | NOVARTIS AG | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286779-A1 | PYRAZOLOPYRIMIDINES AS LIPID KINASE INHIBITORS | ATR, ATM, CHEK1 | ALDH1A1 4053/4885POLB 780/4885SMN1; SMN2 2315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.