Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379431 | 0.90 | SIGMAR1 (0.51) | SIGMAR1OPRD1ALDH1A1USP2TSHR | |
| SCHEMBL4537418 | 0.87 | ALDH1A1 (0.39) | OPRD1ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL4292571 | 0.86 | ALDH1A1 (0.39) | OPRD1ALDH1A1USP2POLBCHRM2 | |
| SCHEMBL4299853 | 0.80 | SIGMAR1 (0.38) | SIGMAR1OPRD1ALDH1A1USP2TSHR | |
| SCHEMBL5717885 | 0.76 | SIGMAR1 (0.45) | SIGMAR1OPRD1ALDH1A1USP2TSHR | |
| SCHEMBL8325473 | 0.76 | FFAR1 (0.44) | SIGMAR1OPRD1ALDH1A1USP2TSHR | |
| Hydrochloric Acid SCHEMBL5849112 | 0.75 | SIGMAR1 (0.44) | SIGMAR1OPRD1ALDH1A1USP2TSHR | |
| SCHEMBL6404717 | 0.73 | BACE1 (0.47) | SIGMAR1OPRD1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL17295878 | 0.72 | OPRD1 (0.43) | SIGMAR1OPRD1ALDH1A1USP2TSHR | |
| SCHEMBL15273036 | 0.72 | SIGMAR1 (0.41) | SIGMAR1OPRD1ALDH1A1USP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286779-A1 | PYRAZOLOPYRIMIDINES AS LIPID KINASE INHIBITORS | NOVARTIS AG | 2009-11-19 | — | — | US | disclosed |
| EP-2081933-A1 | PYRAZOLOPYRIMIDINES AS P13K LIPID KINASE INHIBITORS | Novartis Ag (CH) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008037477-A1 | PYRAZOLOPYRIMIDINES AS P13K LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286779-A1 | PYRAZOLOPYRIMIDINES AS LIPID KINASE INHIBITORS | ATR, ATM, CHEK1 | SIGMAR1 4376/4885OPRD1 4587/4885ALDH1A1 4053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.