Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4299855 | 0.90 | SIGMAR1 (0.42) | SIGMAR1ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL8325473 | 0.84 | FFAR1 (0.44) | SIGMAR1ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL5717885 | 0.82 | SIGMAR1 (0.45) | SIGMAR1ALDH1A1USP2TSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL5849112 | 0.81 | SIGMAR1 (0.44) | SIGMAR1ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL4299853 | 0.80 | SIGMAR1 (0.38) | SIGMAR1ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL6404717 | 0.79 | BACE1 (0.47) | SIGMAR1ALDH1A1TSHRHSD17B10OPRD1 | |
| SCHEMBL15273036 | 0.78 | SIGMAR1 (0.41) | SIGMAR1ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL17295878 | 0.78 | OPRD1 (0.43) | SIGMAR1ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL8715002 | 0.77 | SIGMAR1 (0.51) | SIGMAR1ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL28770204 | 0.76 | SIGMAR1 (0.50) | SIGMAR1ALDH1A1USP2TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9636341-B2 | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2017-05-02 | — | — | US | disclosed |
| US-20150342950-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-03 | — | — | US | disclosed |
| US-9150543-B2 | Substituted indolyl alkyl amino derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N. V. (BE) | 2015-10-06 | — | — | US | disclosed |
| EP-1885710-B1 | SUBSTITUTED AMINOPROPENYL PIPERIDINE OR MORPHOLINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA NV (BE) | 2015-08-19 | — | — | EP | disclosed |
| US-20150197497-A1 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE ISOFORM 6 AND METHODS THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-07-16 | — | — | US | disclosed |
| US-9078896-B2 | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA, N.V. (BE) | 2015-07-14 | — | — | US | disclosed |
| US-20140309248-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2014-10-16 | — | — | US | disclosed |
| US-20140135341-A1 | Pyridine And Pyrimidine Derivatives As Inhibitors Of Histone Deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2014-05-15 | — | — | US | disclosed |
| EP-2723338-A2 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE ISOFORM 6 AND METHODS THEREOF | The Trustees of Stevens Institute of Technology (US) | 2014-04-30 | — | — | EP | disclosed |
| EP-1981875-B1 | SUBSTITUTED INDOLYL-ALKYL-AMINO-DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA NV (BE) | 2014-04-16 | — | — | EP | disclosed |
| WO-2007082880-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-26 | — | — | WO | disclosed |
| WO-2007082878-A1 | AMINOPHENYL DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-26 | — | — | WO | disclosed |
| US-20070135424-A1 | SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN-CILAG (BE) | 2007-06-14 | — | — | US | disclosed |
| EP-1781639-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-09 | — | — | EP | disclosed |
| WO-2007048767-A1 | SQUARIC ACID DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-03 | — | — | WO | disclosed |
| EP-1776358-A2 | SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006136553-A1 | IMIDAZOLINONE AND HYDANTOINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-28 | — | — | WO | disclosed |
| WO-2006122926-A1 | SUBSTITUTED AMINOPROPENYL PIPERIDINE OR MORPHOLINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-11-23 | — | — | WO | disclosed |
| WO-2006010749-A2 | SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-02-02 | — | — | WO | disclosed |
| WO-2006010750-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140135341-A1 | Pyridine And Pyrimidine Derivatives As Inhibitors Of Histone Deacetylase | HDAC1, HDAC11, HDAC3 | SIGMAR1 3352/4885ALDH1A1 318/4885USP2 2441/4885 |
| US-20140309248-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | SIGMAR1 2226/4885ALDH1A1 636/4885USP2 1460/4885 |
| US-20070135424-A1 | SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | SIGMAR1 2413/4885ALDH1A1 399/4885USP2 815/4885 |
| US-20150342950-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | SIGMAR1 2530/4885ALDH1A1 641/4885USP2 1162/4885 |
| US-20150197497-A1 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE ISOFORM 6 AND METHODS THEREOF | HDAC6, HDAC5, HDAC1 | SIGMAR1 4153/4885ALDH1A1 1381/4885USP2 2054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.