Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 9/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 9/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535739 | 0.95 | EPHX2 (0.54) | EPHX1EPHX2ALDH1A1LMNANPSR1 | |
| SCHEMBL4542200 | 0.90 | LMNA (0.54) | EPHX1EPHX2LMNA | |
| SCHEMBL4540005 | 0.88 | LMNA (0.57) | EPHX1EPHX2HTTLMNANPSR1 | |
| SCHEMBL4542921 | 0.88 | CYP3A4 (0.57) | EPHX1EPHX2NPC1ALDH1A1 | |
| SCHEMBL8060768 | 0.88 | LMNA (0.57) | EPHX1EPHX2HTTLMNANPSR1 | |
| SCHEMBL8062904 | 0.88 | EPHX2 (0.59) | EPHX1EPHX2ALDH1A1 | |
| SCHEMBL4537319 | 0.87 | ALDH1A1 (0.52) | EPHX1NPC1HTTALDH1A1LMNA | |
| SCHEMBL4541786 | 0.87 | NPC1 (0.55) | NPC1HTTALDH1A1LMNATSHR | |
| SCHEMBL4537075 | 0.87 | CYP19A1 (0.53) | EPHX1EPHX2HTTALDH1A1LMNA | |
| SCHEMBL4541299 | 0.85 | EPHX1 (0.51) | EPHX1EPHX2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |