Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535853 | 0.95 | FBP1 (0.46) | KMT2AALDH1A1MEN1FBP1HSD11B1 | |
| SCHEMBL4540834 | 0.90 | HSD11B1 (0.47) | KMT2AALDH1A1MEN1FBP1HSD11B1 | |
| SCHEMBL4542443 | 0.89 | FBP1 (0.50) | KMT2AALDH1A1MEN1FBP1HSD11B1 | |
| SCHEMBL8062169 | 0.89 | FBP1 (0.50) | KMT2AALDH1A1MEN1FBP1HSD11B1 | |
| SCHEMBL4537741 | 0.89 | EPHX2 (0.44) | KMT2AALDH1A1MEN1LMNAGAA | |
| SCHEMBL4541025 | 0.89 | MEN1 (0.50) | KMT2AALDH1A1MEN1LMNAGAA | |
| SCHEMBL4536850 | 0.87 | EPHX1 (0.52) | KMT2AALDH1A1MEN1FBP1HSD11B1 | |
| SCHEMBL8065003 | 0.86 | KMT2A (0.41) | KMT2AALDH1A1MEN1FBP1HSD11B1 | |
| SCHEMBL4542877 | 0.86 | HSD11B1 (0.44) | KMT2AALDH1A1MEN1FBP1HSD11B1 | |
| SCHEMBL4537312 | 0.85 | P2RX7 (0.43) | KMT2AALDH1A1MEN1HTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |