Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHKA | P35790 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hexamethyl Pararosaniline SCHEMBL455550 | 0.85 | ALDH1A1 (0.61) | ALDH1A1TSHRALOX15HSD17B10MAPT | |
| SCHEMBL146321 | 0.85 | ALDH1A1 (0.61) | ALDH1A1TSHRALOX15HSD17B10MAPT | |
| Hydrochloric Acid SCHEMBL10664947 | 0.83 | ALDH1A1 (0.58) | ALDH1A1TSHRALOX15HSD17B10MAPT | |
| Hydrochloric Acid SCHEMBL9693558 | 0.83 | ALDH1A1 (0.58) | ALDH1A1TSHRALOX15HSD17B10MAPT | |
| Hexamethyl Pararosaniline SCHEMBL30271599 | 0.82 | ALDH1A1 (0.65) | ALDH1A1TSHRALOX15HSD17B10MAPT | |
| SCHEMBL5530195 | 0.79 | ALDH1A1 (0.52) | ALDH1A1TSHRALOX15HSD17B10MAPT | |
| Brilliant Green SCHEMBL608624 | 0.77 | ALDH1A1 (0.50) | ALDH1A1TSHRALOX15HSD17B10MAPT | |
| SCHEMBL9694680 | 0.75 | ALDH1A1 (0.70) | ALDH1A1TSHRALOX15HSD17B10MAPT | |
| SCHEMBL9806735 | 0.74 | ALDH1A1 (0.61) | ALDH1A1TSHRALOX15HSD17B10MAPT | |
| SCHEMBL9627045 | 0.73 | SLC2A1 (0.55) | ALDH1A1TSHRALOX15HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 251 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003022233-A1 | AGENT FOR DYEING KERATIN FIBERS, CONTAINING A BLUE CATIONIC ANTHRAQUINONE DYE | WELLA AKTIENGESELLSCHAFT (DE) | 2003-03-20 | — | — | WO | claimed |
| EP-2930126-B1 | Fashionable aerosol dye | HENKEL AG & CO KGAA (DE) | 2019-10-09 | — | — | EP | disclosed |
| US-10259946-B1 | Sealing agents, methods of making and uses thereof | James Hardie Technology Limited (IE) | 2019-04-16 | — | — | US | disclosed |
| EP-2797577-B1 | COMPOSITIONS FOR DYEING KERATIN FIBERS | HENKEL AG & CO KGAA (DE) | 2018-06-13 | — | — | EP | disclosed |
| US-9901529-B2 | Hair color composition | ALFA PARF GROUP S.P.A. (IT) | 2018-02-27 | — | — | US | disclosed |
| EP-2044977-B1 | Hair dye with oxidative pre-treatment | HENKEL AG & CO KGAA (DE) | 2018-02-14 | — | — | EP | disclosed |
| EP-2324811-B1 | Foam-like dye | HENKEL AG & CO KGAA (DE) | 2018-01-03 | — | — | EP | disclosed |
| EP-2802383-B1 | USE OF PROPYLENE OXIDE-MODIFIED STARCH FOR IMPROVING ARTIFICIAL COLOURING OF KERATIN FIBRES | HENKEL AG & CO KGAA (DE) | 2018-01-03 | — | — | EP | disclosed |
| US-20170273881-A1 | COSMETIC COMPOSITION FOR KERATIN FIBRES | ALFA PARF GROUP S.P.A. (IT) | 2017-09-28 | — | — | US | disclosed |
| US-20170105921-A1 | HAIR COLOR COMPOSITION | ALFA PARF GROUP S.P.A. (IT) | 2017-04-20 | — | — | US | disclosed |
| US-6171347-B1 | REMOVAL OF HAIR COLOR TO BE WORN FOR ONLY A SHORT PERIOD OF TIME UNDER MILD, GENTLE CONDITIONS BY USING A COMBINATION OF A SUITABLE REDUCTONE, SUCH AS ASCORBIC ACID, AND/OR A THIOL AND/OR A SULFITE | WELLA AKTIENGESELLSCHAFT (DE) | 2001-01-09 | — | — | US | disclosed |
| US-6106579-A | MIXTURE OF OXOCARBOXYLIC ACID AND REDUCING AGENT | WELLA AKTIENGESELLSCHAFT (DE) | 2000-08-22 | — | — | US | disclosed |
| EP-1002516-A1 | Hair dyes containing indan derivatives | Wella Aktiengesellschaft (DE) | 2000-05-24 | — | — | EP | disclosed |
| EP-0943316-A2 | Means for coloring and decoloring of hair | Wella Aktiengesellschaft (DE) | 1999-09-22 | — | — | EP | disclosed |
| EP-0898954-A2 | Composition for dyeing keratin fibres | Wella Aktiengesellschaft (DE) | 1999-03-03 | — | — | EP | disclosed |
| EP-0889719-A1 | AGENTS FOR DYING AND DECOLORIZING FIBERS | Wella Aktiengesellschaft (DE) | 1999-01-13 | — | — | EP | disclosed |
| EP-0877593-A1 | AGENT FOR DYEING AND DECOLORIZING FIBERS | Wella Aktiengesellschaft (DE) | 1998-11-18 | — | — | EP | disclosed |
| EP-0867171-A2 | Powder composition for the preparation of gels comprising a methyl hydroxyalkyl cellulose | Wella Aktiengesellschaft (DE) | 1998-09-30 | — | — | EP | disclosed |
| WO-1998023247-A1 | AGENT FOR DYEING AND DECOLORIZING FIBERS | WELLA AKTIENGESELLSCHAFT (DE) | 1998-06-04 | — | — | WO | disclosed |
| WO-1998022078-A1 | AGENTS FOR DYING AND DECOLORIZING FIBERS | WELLA AKTIENGESELLSCHAFT (DE) | 1998-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170273881-A1 | COSMETIC COMPOSITION FOR KERATIN FIBRES | KRT18, GRHPR, CUTA | ALDH1A1 1728/4885TSHR 4753/4885ALOX15 2396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.