Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 13/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.47 |
| ▸ | BCHE | P06276 | 4/20 | 0.47 |
| ▸ | ACHE | P22303 | 4/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6404056 | 1.00 | CHRM2 (0.58) | CHRM2ATML3MBTL1GRIN1GRIN2A | |
| SCHEMBL6313952 | 0.89 | L3MBTL1 (0.54) | CHRM2ATML3MBTL1GRIN1GRIN2A | |
| SCHEMBL20988035 | 0.83 | ATM (0.63) | CHRM2ATML3MBTL1GRIN1GRIN2A | |
| SCHEMBL5136256 | 0.82 | CHRM2 (0.43) | CHRM2ALDH1A1 | |
| SCHEMBL6398519 | 0.81 | LMNA (0.43) | CHRM2CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL20584486 | 0.75 | CHRM2 (0.80) | CHRM2GRIN1GRIN2ABCHEACHE | |
| SCHEMBL4373386 | 0.75 | CHRM2 (0.97) | CHRM2GRIN1GRIN2ABCHEACHE | |
| SCHEMBL10288228 | 0.73 | KDM4E (0.40) | CHRM2ATML3MBTL1TSHRALDH1A1 | |
| SCHEMBL27725768 | 0.73 | CHRM2 (0.54) | CHRM2GRIN1GRIN2ABCHEACHE | |
| SCHEMBL29263690 | 0.72 | TAAR1 (0.72) | CHRM2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034457-A1 | ORGANIC COMPOUNDS USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES, USES AND METHODS FOR THE PREPARATION THEREOF | ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA (IT) | 2009-03-19 | — | — | WO | disclosed |
| US-20070299093-A1 | Organic Compounds Useful for the Treatment of Alzheimer's Disease, Their Use and Method of Preparation | Alma Mater Studiorum-Universitá Di Bologna (IT) | 2007-12-27 | — | — | US | disclosed |
| US-7307083-B2 | Tetrahydro-acridine and dithiolane derivatives | ALMA MATER STUDIORUM-UNIVERSITA'DI BOLOGNA (IT) | 2007-12-11 | — | — | US | disclosed |
| US-20070219241-A1 | Organic Compounds Useful For The Treatment Of Alzheimer's Disease, Their Use And Method Of Preparation | ALMA MATER STUDIORUM-UNIVERSITA'DI BOLOGNA (IT) | 2007-09-20 | — | — | US | disclosed |
| EP-1497257-A1 | 2,5-BIS-DIAMINE-[1,4] BENZOQUINONE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE, A PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THEREFOR | Alma Mater Studiorum -Universita' di Bologna (IT) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003087035-A1 | 2,5-BIS-DIAMINE-'1,4! BENZOQUINONE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE A PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THEREFOR | ALMA MATER STUDIORUM-UNIVERSITA' DI BOLOGNA (IT) | 2003-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219241-A1 | Organic Compounds Useful For The Treatment Of Alzheimer's Disease, Their Use And Method Of Preparation | OTC, PSEN2, PSEN1 | CHRM2 207/4885ATM 1848/4885L3MBTL1 4205/4885 |
| US-20070299093-A1 | Organic Compounds Useful for the Treatment of Alzheimer's Disease, Their Use and Method of Preparation | OTC, PSEN2, PSEN1 | CHRM2 207/4885ATM 1848/4885L3MBTL1 4205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.