Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | F9 | P00740 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3601806 | 0.86 | ALOX5 (0.49) | ALDH1A1HSD17B10HPGDMAPTADORA2A | |
| SCHEMBL3606784 | 0.81 | ALDH1A1 (0.49) | ALDH1A1HSD17B10HPGDTSHRMAPT | |
| SCHEMBL3609977 | 0.79 | ALDH1A1 (0.64) | ALDH1A1HSD17B10HPGDTSHRMAPT | |
| SCHEMBL3599172 | 0.78 | KMO (0.52) | ALDH1A1HSD17B10HPGDTSHRMAPT | |
| SCHEMBL8558589 | 0.76 | MEN1 (0.46) | ALDH1A1HSD17B10HPGDTSHRMAPT | |
| SCHEMBL8560935 | 0.73 | ALDH1A1 (0.40) | ALDH1A1HSD17B10HPGDTSHRMAPT | |
| SCHEMBL3609627 | 0.72 | ALDH1A1 (0.51) | ALDH1A1HSD17B10HPGDMAPTKDM4E | |
| SCHEMBL3597588 | 0.71 | PLTP (0.46) | ALDH1A1HSD17B10HPGDTSHRMAPT | |
| SCHEMBL14960379 | 0.71 | ALDH1A1 (0.74) | ALDH1A1HSD17B10HPGDTSHRMAPT | |
| SCHEMBL3606351 | 0.70 | PLTP (0.43) | ALDH1A1HSD17B10HPGDTSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010508-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120096-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |