Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CCKAR | P32238 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 6/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558589 | 0.90 | MEN1 (0.46) | ALDH1A1HPGDTSHRHSD17B10MAPT | |
| SCHEMBL8560930 | 0.82 | KMT2A (0.41) | ALDH1A1HPGDTSHRHSD17B10MAPT | |
| SCHEMBL9125041 | 0.79 | MAPT (0.42) | ALDH1A1HPGDTSHRHSD17B10MAPT | |
| SCHEMBL8560928 | 0.78 | KMT2A (0.39) | ALDH1A1TSHRMEN1CCKARKMT2A | |
| SCHEMBL4538756 | 0.73 | ALDH1A1 (0.49) | ALDH1A1HPGDTSHRHSD17B10MAPT | |
| SCHEMBL8558581 | 0.72 | KMT2A (0.49) | ALDH1A1HPGDTSHRHSD17B10MAPT | |
| SCHEMBL9125033 | 0.71 | TRPV4 (0.41) | ALDH1A1HPGDTSHRHSD17B10MAPT | |
| SCHEMBL8558579 | 0.67 | KMT2A (0.48) | ALDH1A1TSHRHSD17B10MEN1CCKAR | |
| SCHEMBL19410240 | 0.67 | KMT2A (0.52) | ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL3958982 | 0.67 | CCR2 (0.56) | ALDH1A1TSHRMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518731-B1 | 2-(Indol-2-yl-carbonylamino)-thiazole derivatives, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1998-08-26 | — | — | EP | disclosed |
| US-5380736-A | Cholecystokinin and gastric antagonist | ELF SANOFI (FR) | 1995-01-10 | — | — | US | disclosed |
| US-5314889-A | Hormone antagonists | ELF SANOFI (FR) | 1994-05-24 | — | — | US | disclosed |
| EP-0518731-A1 | Heterocyclic derivatives of substituted 2-acylamino 5-thiazole, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-12-16 | — | — | EP | disclosed |