Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541107 | 0.91 | MEN1 (0.49) | MAPK1PDE2AEGLN1ADRB2EPHX2 | |
| SCHEMBL4538848 | 0.89 | SCN3A (0.47) | MAPK1EGLN1HPGDSMN1; SMN2SCN3A | |
| SCHEMBL4540440 | 0.88 | MAPK14 (0.48) | MAPK1SMN1; SMN2PTGER4LMNACYP3A4 | |
| SCHEMBL4540761 | 0.87 | PTGER4 (0.52) | SMN1; SMN2PTGER4CYP3A4 | |
| SCHEMBL4543760 | 0.87 | PTGER4 (0.41) | MAPK1SMN1; SMN2PTGER4LMNACYP3A4 | |
| SCHEMBL4543960 | 0.86 | GRM5 (0.43) | MAPK1EGLN1PTGER4CYP3A4 | |
| SCHEMBL4540280 | 0.84 | DGAT2 (0.44) | EGLN1CYP2C9HPGDCYP2C19CYP1A2 | |
| SCHEMBL4539445 | 0.83 | MEN1 (0.54) | MAPK1PDE2AEGLN1ADRB2EPHX2 | |
| SCHEMBL4542986 | 0.81 | MEN1 (0.49) | MAPK1ALDH1A1HPGDCYP2C19CYP1A2 | |
| SCHEMBL4543630 | 0.80 | MEN1 (0.53) | CYP2C9CYP2C19CYP1A2SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |