Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | CCR9 | P51686 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542986 | 0.94 | MEN1 (0.49) | MAPK14CYP3A4MEN1KMT2APPARG | |
| SCHEMBL4543760 | 0.91 | PTGER4 (0.41) | MAPK14CYP3A4MEN1KMT2APPARG | |
| SCHEMBL4543960 | 0.91 | GRM5 (0.43) | MAPK14CYP3A4MEN1KMT2APPARG | |
| SCHEMBL4540761 | 0.90 | PTGER4 (0.52) | MAPK14CYP3A4PTGER4PTGER2SMN1; SMN2 | |
| SCHEMBL4543630 | 0.89 | MEN1 (0.53) | MAPK14CYP3A4MEN1KMT2APPARG | |
| SCHEMBL4538837 | 0.88 | MAPK1 (0.46) | CYP3A4PTGER4MAPK1LMNASMN1; SMN2 | |
| SCHEMBL4541107 | 0.85 | MEN1 (0.49) | CYP3A4MEN1KMT2APPARGNR2E3 | |
| SCHEMBL4544058 | 0.84 | MEN1 (0.59) | MAPK14CYP3A4MEN1KMT2APPARG | |
| SCHEMBL4540280 | 0.83 | DGAT2 (0.44) | MEN1KMT2APPARGNR2E3NCOR2 | |
| SCHEMBL4540206 | 0.82 | MAPK14 (0.48) | MAPK14CYP3A4MEN1KMT2APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |