Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4543960 | 0.90 | GRM5 (0.43) | DGAT2EGLN1MEN1PPARGKMT2A | |
| SCHEMBL4538837 | 0.84 | MAPK1 (0.46) | EGLN1FLT1KDRTRPV1CYP1A2 | |
| SCHEMBL4540440 | 0.83 | MAPK14 (0.48) | MEN1PPARGKMT2ANR2E3NCOR2 | |
| SCHEMBL4542661 | 0.83 | MEN1 (0.58) | DGAT2EGLN1KITMEN1PPARG | |
| SCHEMBL4538848 | 0.82 | SCN3A (0.47) | EGLN1MEN1PPARGKMT2ANR2E3 | |
| SCHEMBL4543760 | 0.82 | PTGER4 (0.41) | DGAT2MEN1PPARGKMT2ANR2E3 | |
| SCHEMBL4540559 | 0.81 | MEN1 (0.51) | MEN1PPARGKMT2ANR2E3NCOR2 | |
| SCHEMBL4540761 | 0.80 | PTGER4 (0.52) | P2RX7 | |
| SCHEMBL4542986 | 0.77 | MEN1 (0.49) | MEN1PPARGKMT2ANR2E3NCOR2 | |
| SCHEMBL4541107 | 0.77 | MEN1 (0.49) | EGLN1MEN1PPARGKMT2ANR2E3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |