Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN3A | Q9NY46 | 6/20 | 0.47 |
| ▸ | SCN1A | P35498 | 2/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4538837 | 0.89 | MAPK1 (0.46) | SCN3AHPGDSMN1; SMN2MAPK1EGLN1 | |
| SCHEMBL4543756 | 0.84 | MEN1 (0.53) | SCN3ASCN1ASCN5ASCN9ASCN2A | |
| SCHEMBL4540280 | 0.82 | DGAT2 (0.44) | KCNH2P2RX7MEN1PPARGKMT2A | |
| SCHEMBL4540440 | 0.81 | MAPK14 (0.48) | MEN1PPARGKMT2ANR2E3NCOR2 | |
| SCHEMBL4541107 | 0.80 | MEN1 (0.49) | SCN5ASCN9AKCNH2MEN1PPARG | |
| SCHEMBL4543760 | 0.80 | PTGER4 (0.41) | P2RX7MEN1PPARGKMT2ANR2E3 | |
| SCHEMBL4540761 | 0.80 | PTGER4 (0.52) | P2RX7SMN1; SMN2 | |
| SCHEMBL4543960 | 0.79 | GRM5 (0.43) | SCN9ASCN8ASCN10AMEN1PPARG | |
| SCHEMBL4540559 | 0.77 | MEN1 (0.51) | MEN1PPARGKMT2ANR2E3NCOR2 | |
| SCHEMBL4540218 | 0.75 | MEN1 (0.65) | SCN3AMEN1PPARGKMT2ANR2E3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |