Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 7/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4536998 | 0.97 | BDKRB1 (0.49) | BDKRB1HSD11B1HCRTR1HCRTR2KMT2A | |
| SCHEMBL4537661 | 0.89 | HTR1A (0.48) | BDKRB1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4541294 | 0.88 | PSEN1 (0.56) | BDKRB1ALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL4537242 | 0.88 | NPC1 (0.53) | BDKRB1HSD11B1KMT2ANPC1RAB9A | |
| SCHEMBL4539341 | 0.87 | EPHX1 (0.48) | BDKRB1HSD11B1RAB9ALMNATSHR | |
| SCHEMBL4535072 | 0.86 | BDKRB1 (0.56) | BDKRB1KMT2AMEN1 | |
| SCHEMBL4541345 | 0.86 | POLB (0.44) | BDKRB1HSD11B1KMT2ANPC1RAB9A | |
| SCHEMBL4535231 | 0.86 | HTR7 (0.52) | BDKRB1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4542494 | 0.86 | HTR7 (0.52) | BDKRB1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4542928 | 0.85 | LMNA (0.55) | BDKRB1HCRTR1HCRTR2ALDH1A1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |