Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | F10 | P00742 | 7/20 | 0.39 |
| ▸ | F11 | P03951 | 7/20 | 0.39 |
| ▸ | F7 | P08709 | 7/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.35 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.35 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45258 | 0.90 | F11 (0.37) | ALDH1A1F10F11F7CYP2C19 | |
| SCHEMBL45015 | 0.89 | MAPT (0.40) | ALDH1A1TDP1USP2GAASIRT2 | |
| SCHEMBL45781 | 0.88 | F10 (0.45) | ALDH1A1F10F11F7CYP2C19 | |
| SCHEMBL11025709 | 0.88 | F7 (0.44) | ALDH1A1F10F11F7CYP2C19 | |
| SCHEMBL11026479 | 0.86 | CYP2C19 (0.41) | ALDH1A1F10F11F7CYP2C19 | |
| SCHEMBL41549 | 0.85 | KMO (0.52) | ALDH1A1F10F11F7CYP2C19 | |
| SCHEMBL45198 | 0.84 | PRKAG1 (0.47) | ALDH1A1CYP2C19USP2GAACYP3A4 | |
| SCHEMBL11026483 | 0.83 | F10 (0.45) | ALDH1A1F10F11F7CYP2C19 | |
| SCHEMBL45312 | 0.82 | F10 (0.47) | ALDH1A1F10F11F7CYP2C19 | |
| SCHEMBL11025215 | 0.81 | MRGPRX4 (0.43) | ALDH1A1F10F11F7CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120004218-A1 | NOVEL TETRAHYDRO-QUINOLINE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004218-A1 | NOVEL TETRAHYDRO-QUINOLINE DERIVATIVES | GPR119, PRKAB1, PRKAG1 | ALDH1A1 361/4885TDP1 1040/4885F10 2676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.