Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541794 | 0.97 | HSD11B1 (0.54) | HSD11B1TP53BDKRB2BDKRB1 | |
| SCHEMBL4534767 | 0.91 | FAAH (0.41) | HSD11B1TP53 | |
| SCHEMBL4537066 | 0.88 | FAAH (0.42) | HSD11B1 | |
| SCHEMBL4542938 | 0.85 | HSD11B1 (0.51) | HSD11B1TP53 | |
| SCHEMBL4539752 | 0.84 | HSD11B1 (0.56) | HSD11B1BDKRB2BDKRB1 | |
| SCHEMBL4530195 | 0.84 | NPC1 (0.47) | — | |
| SCHEMBL4539656 | 0.83 | POLB (0.40) | BDKRB1 | |
| SCHEMBL4539344 | 0.81 | BDKRB1 (0.48) | BDKRB1 | |
| SCHEMBL4542098 | 0.81 | HTR1A (0.48) | — | |
| SCHEMBL4537246 | 0.81 | HSD11B1 (0.56) | HSD11B1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |