Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.43 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542462 | 0.90 | RAB9A (0.46) | HSD11B1RAB9A | |
| SCHEMBL4531367 | 0.87 | RAB9A (0.43) | HSD11B1RAB9A | |
| SCHEMBL4541794 | 0.87 | HSD11B1 (0.54) | HSD11B1BDKRB2BDKRB1 | |
| SCHEMBL4537325 | 0.86 | MEN1 (0.51) | RAB9A | |
| SCHEMBL4539833 | 0.84 | HSD11B1 (0.53) | HSD11B1BDKRB2BDKRB1 | |
| SCHEMBL4533525 | 0.83 | KMT2A (0.48) | RAB9A | |
| SCHEMBL4539750 | 0.83 | HSD11B1 (0.52) | HSD11B1 | |
| SCHEMBL4531620 | 0.83 | HSD11B1 (0.58) | HSD11B1 | |
| SCHEMBL4530295 | 0.82 | POLB (0.44) | RAB9A | |
| SCHEMBL4533331 | 0.80 | HTR1A (0.56) | RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |