SCHEMBL4540271

SCHEMBL4540271

CSc1ccc2nc(C)ccc2c1

nearest known ligand 0.63

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.63
KDM4E B2RXH2 2/20 0.59
LMNA P02545 1/20 0.59
POLB P06746 1/20 0.59
CASP6 P55212 1/20 0.59
KDM1A O60341 1/20 0.42
RAB9A P51151 4/20 0.41
NPC1 O15118 3/20 0.41
CCR1 P32246 1/20 0.41
CCR5 P51681 1/20 0.41
TYMS P04818 1/20 0.41
TERT O14746 1/20 0.40
NCK1 P16333 1/20 0.39
BACE1 P56817 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2959829 0.87 CYP1A2 (0.63) CYP1A2KDM4ELMNAPOLBCASP6
SCHEMBL16289589 0.79 CYP1A2 (0.39) CYP1A2KDM4ELMNAPOLBCASP6
SCHEMBL28234146 0.79 CYP1A2 (0.39) CYP1A2KDM4ELMNAPOLBCASP6
SCHEMBL161703 0.77 CYP1A2 (1.00) CYP1A2KDM4ELMNAPOLBCASP6
SCHEMBL29444268 0.77 CYP1A2 (1.00) CYP1A2KDM4ELMNAPOLBCASP6
SCHEMBL23980624 0.76 NCF1 (0.40) CYP1A2KDM4ELMNAPOLBCASP6
SCHEMBL20049392 0.76 FGFR1 (0.37) CYP1A2KDM4ELMNAPOLBCASP6
SCHEMBL9022233 0.76 AKR1C3 (0.40) CYP1A2KDM4ELMNAPOLBCASP6
SCHEMBL7837077 0.76 CYP1A2 (0.37) CYP1A2KDM4ELMNAPOLBCASP6
SCHEMBL10259445 0.76 CYP1A2 (0.68) CYP1A2KDM4ELMNAPOLBCASP6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019182743-A1 COMPOSITIONS FOR THE TREATMENT OF BRAIN TUMORS INNOCRIN PHARMACEUTICALS, INC. (US) 2019-09-26 WO disclosed
EP-2952096-B1 Amide compound, an arthropod pest control agent and a method for controlling arthropod pest SUMITOMO CHEMICAL CO (JP) 2018-04-04 EP disclosed
US-9814235-B2 Method for controlling arthropod pest SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2017-11-14 US disclosed
EP-2952096-A1 METHOD FOR CONTROLLING ARTHROPOD PEST Sumitomo Chemical Company, Limited (JP) 2015-12-09 EP disclosed
US-20150344466-A1 METHOD FOR CONTROLLING ARTHROPOD PEST SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-12-03 US disclosed
US-20150005348-A1 AMIDE COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-01-01 US disclosed
EP-2813492-A1 AMIDE COMPOUND AND USE THEREOF FOR PEST CONTROL Sumitomo Chemical Co., Ltd (JP) 2014-12-17 EP disclosed
EP-2638021-A2 METALLOENZYME INHIBITOR COMPOUNDS Viamet Pharmaceuticals, Inc. (US) 2013-09-18 EP disclosed
WO-2012064943-A2 METALLOENZYME INHIBITOR COMPOUNDS VIAMET PHARMACEUTICALS, INC. (US) 2012-05-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150344466-A1 METHOD FOR CONTROLLING ARTHROPOD PEST H1-0, H1-3, H1-2 CYP1A2 193/4885KDM4E 1006/4885LMNA 3984/4885
US-20150005348-A1 AMIDE COMPOUND AND USE THEREOF FOR PEST CONTROL RPS8, MT-CO2, ARG1 CYP1A2 355/4885KDM4E 1028/4885LMNA 3662/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.