Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PGK1 | P00558 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | AOC1 | P19801 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1236060 | 0.81 | ROCK2 (0.50) | MKNK1MKNK2SIRT3TDP1AOC1 | |
| SCHEMBL1234651 | 0.79 | SIRT3 (0.54) | MKNK1MKNK2SIRT3TDP1AOC1 | |
| SCHEMBL4543738 | 0.77 | GSK3B (0.40) | MKNK1MKNK2SIRT3TDP1AOC1 | |
| SCHEMBL2122995 | 0.69 | MKNK1 (0.57) | MKNK1MKNK2ALDH1A1HSD17B10SIRT3 | |
| SCHEMBL26628263 | 0.66 | ALDH1A1 (0.36) | MEN1ALDH1A1KMT2AHSD17B10PTK2 | |
| SCHEMBL4540580 | 0.66 | MAPK8 (0.50) | MKNK1MKNK2MEN1ALDH1A1KMT2A | |
| SCHEMBL23790598 | 0.65 | ALDH1A1 (0.39) | ALDH1A1PGK1TDP1SMN1; SMN2MAPK1 | |
| SCHEMBL10249889 | 0.65 | NNMT (0.44) | MKNK1MKNK2ALDH1A1HSD17B10SIRT2 | |
| SCHEMBL4540577 | 0.64 | PGK1 (0.44) | MKNK1MKNK2MEN1ALDH1A1KMT2A | |
| SCHEMBL10799783 | 0.63 | ALDH1A1 (0.58) | MEN1ALDH1A1KMT2ASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009140164-A1 | 6-AMINONICOTINAMIDE DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES LTD. (CN) | 2009-11-19 | — | — | WO | disclosed |