Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537002 | 0.93 | RAB9A (0.44) | ALDH1A1RAB9APAX8TSHR | |
| SCHEMBL4542350 | 0.92 | RAB9A (0.43) | KMT2ARAB9APAX8MEN1TSHR | |
| SCHEMBL4539816 | 0.86 | RAB9A (0.60) | HCRTR1HCRTR2RAB9APAX8 | |
| SCHEMBL4542326 | 0.85 | RAB9A (0.47) | KMT2AALDH1A1RAB9APOLBMEN1 | |
| SCHEMBL4535257 | 0.85 | RAB9A (0.53) | ALDH1A1RAB9APAX8TSHR | |
| SCHEMBL4537168 | 0.84 | RAB9A (0.47) | RAB9APAX8TSHR | |
| SCHEMBL4536862 | 0.84 | ALDH1A1 (0.52) | HCRTR1HCRTR2ALDH1A1RAB9APOLB | |
| SCHEMBL4536848 | 0.83 | HTR1A (0.48) | RAB9AEPHX2 | |
| SCHEMBL4540631 | 0.83 | RAB9A (0.51) | HCRTR1HCRTR2KMT2AALDH1A1RAB9A | |
| SCHEMBL4541691 | 0.83 | ALDH1A1 (0.44) | KMT2AALDH1A1RAB9AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |