Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4533327 | 0.97 | HTR1A (0.52) | HTR1ADRD2HTR1DHTR1BHTR7 | |
| SCHEMBL4530967 | 0.90 | HTR7 (0.48) | HTR1ADRD2HTR1DHTR1BHTR7 | |
| SCHEMBL8062041 | 0.89 | RAB9A (0.47) | RAB9A | |
| SCHEMBL4538141 | 0.89 | BDKRB1 (0.46) | RAB9A | |
| SCHEMBL4535257 | 0.88 | RAB9A (0.53) | RAB9A | |
| SCHEMBL4537565 | 0.88 | RAB9A (0.51) | RAB9A | |
| SCHEMBL4539816 | 0.88 | RAB9A (0.60) | HTR7RAB9A | |
| SCHEMBL4535463 | 0.88 | HTR7 (0.55) | HTR1ADRD2HTR1DHTR1BHTR7 | |
| SCHEMBL4542096 | 0.87 | HTR1A (0.47) | HTR1ADRD2HTR1DHTR1BHTR7 | |
| SCHEMBL8064995 | 0.86 | BDKRB1 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |