Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | APEX1 | P27695 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4544013 | 0.84 | LDHA (0.40) | POLBL3MBTL1GAAGLATSHR | |
| SCHEMBL4540121 | 0.80 | TDP1 (0.43) | POLBTDP1APEX1L3MBTL1LDHA | |
| SCHEMBL4538950 | 0.80 | POLB (0.43) | POLBTDP1APEX1L3MBTL1KMT2A | |
| SCHEMBL4540738 | 0.78 | L3MBTL1 (0.42) | POLBTDP1APEX1L3MBTL1MAPT | |
| SCHEMBL4539354 | 0.75 | KMO (0.45) | POLBTDP1APEX1L3MBTL1GAA | |
| SCHEMBL8721284 | 0.75 | GRIA1 (0.57) | POLBTDP1APEX1L3MBTL1 | |
| SCHEMBL4540603 | 0.74 | POLB (0.38) | POLBTDP1APEX1L3MBTL1LDHA | |
| SCHEMBL4542152 | 0.73 | CNR2 (0.44) | POLBMAPTTP53CYP3A4 | |
| SCHEMBL4540416 | 0.72 | POLB (0.47) | POLBTDP1APEX1L3MBTL1MAPT | |
| SCHEMBL4542122 | 0.72 | CYP1A2 (0.47) | POLBTDP1APEX1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |