Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4540121 | 0.88 | TDP1 (0.43) | L3MBTL1POLBAPEX1TDP1RAB9A | |
| SCHEMBL4542227 | 0.87 | ALDH1A1 (0.41) | L3MBTL1POLBNPC1RAB9AMEN1 | |
| SCHEMBL4540644 | 0.78 | POLB (0.47) | L3MBTL1POLBAPEX1TDP1RAB9A | |
| SCHEMBL4538964 | 0.76 | LIPG (0.43) | POLBTDP1KMT2ATP53CYP3A4 | |
| SCHEMBL4538950 | 0.75 | POLB (0.43) | L3MBTL1POLBAPEX1TDP1KMT2A | |
| SCHEMBL4539208 | 0.73 | POLB (0.44) | L3MBTL1POLBAPEX1TDP1MAPT | |
| SCHEMBL4543616 | 0.71 | BRD9 (0.40) | L3MBTL1POLBAPEX1TDP1 | |
| SCHEMBL4539354 | 0.71 | KMO (0.45) | L3MBTL1POLBAPEX1TDP1ALDH1A1 | |
| SCHEMBL8721284 | 0.70 | GRIA1 (0.57) | L3MBTL1POLBAPEX1TDP1 | |
| SCHEMBL4540603 | 0.69 | POLB (0.38) | L3MBTL1POLBAPEX1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |