Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.37 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 2/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541733 | 0.84 | CFTR (0.43) | L3MBTL1MAPTNPSR1ALDH1A1KDM4E | |
| SCHEMBL4542122 | 0.83 | CYP1A2 (0.47) | POLBAPEX1TDP1L3MBTL1MAPT | |
| SCHEMBL4539208 | 0.81 | POLB (0.44) | POLBAPEX1TDP1L3MBTL1MAPT | |
| SCHEMBL4960652 | 0.77 | POLB (0.47) | POLBAPEX1TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL4540644 | 0.72 | POLB (0.47) | POLBAPEX1TDP1L3MBTL1MAPT | |
| SCHEMBL422332 | 0.72 | ALDH1A1 (0.62) | TAS2R14ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL4543597 | 0.70 | POLB (0.41) | POLBAPEX1TDP1L3MBTL1MAPT | |
| SCHEMBL29797539 | 0.70 | MAPT (0.45) | POLBAPEX1TDP1L3MBTL1MAPT | |
| SCHEMBL4540543 | 0.69 | MAPT (0.66) | L3MBTL1MAPTNPSR1ALDH1A1PKM | |
| SCHEMBL4540738 | 0.68 | L3MBTL1 (0.42) | POLBAPEX1TDP1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |