Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 12/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542999 | 0.86 | CFTR (0.42) | POLBPTGDR2MRGPRX4MAPTNOTUM | |
| SCHEMBL4542122 | 0.81 | CYP1A2 (0.47) | POLBAPEX1TDP1L3MBTL1MRGPRX4 | |
| SCHEMBL4540416 | 0.81 | POLB (0.47) | POLBAPEX1TDP1L3MBTL1MAPT | |
| SCHEMBL4543818 | 0.78 | POLB (0.65) | POLBAPEX1TDP1L3MBTL1MAPT | |
| SCHEMBL4960652 | 0.75 | POLB (0.47) | POLBAPEX1TDP1L3MBTL1NOTUM | |
| SCHEMBL4541949 | 0.74 | MAPK14 (0.48) | POLBMAPT | |
| SCHEMBL4540738 | 0.73 | L3MBTL1 (0.42) | POLBAPEX1TDP1L3MBTL1MAPT | |
| SCHEMBL421582 | 0.70 | ALDH1A1 (0.59) | MRGPRX4NOTUM | |
| SCHEMBL4540644 | 0.70 | POLB (0.47) | POLBAPEX1TDP1L3MBTL1MAPT | |
| SCHEMBL4540121 | 0.70 | TDP1 (0.43) | POLBAPEX1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |