Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10714813 | 0.87 | CYP2C9 (0.53) | PTGS2PTGS1ABCB11LMNAADORA1 | |
| SCHEMBL11051064 | 0.87 | AKR1B1 (0.50) | PTGS2PTGS1ABCB11LMNAADORA1 | |
| Water SCHEMBL10711418 | 0.85 | AKR1B1 (0.48) | PTGS2PTGS1ABCB11LMNAADORA1 | |
| Water SCHEMBL11052710 | 0.84 | AKR1B1 (0.47) | PTGS2PTGS1ABCB11LMNAADORA1 | |
| SCHEMBL2391613 | 0.83 | FFAR1 (0.53) | PTGS2PTGS1ABCB11LMNAADORA1 | |
| SCHEMBL10713781 | 0.81 | MMP2 (0.56) | FFAR1FFAR4HPGDPTGDR2MEN1 | |
| SCHEMBL16396604 | 0.80 | PTGS2 (0.58) | PTGS2PTGS1ABCB11LMNAADORA1 | |
| SCHEMBL10712603 | 0.79 | PTGS2 (0.51) | PTGS2PTGS1ABCB11LMNAADORA1 | |
| SCHEMBL6901528 | 0.78 | ABCB11 (0.65) | PTGS2PTGS1ABCB11LMNAADORA1 | |
| SCHEMBL7583347 | 0.77 | AKR1B1 (0.58) | PTGS2PTGS1ABCB11LMNAADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629140-B2 | Assay for cytochrome P450 isoform 2C9 | ISTITUTO DI RICHERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2009-12-08 | — | — | US | claimed |
| US-20080193950-A1 | Rapid and sensitive; radiometric; automatic; multiwell plates; incubating with tritium-labeled diclofenac | MERCK SHARP & DOHME CORP. | 2008-08-14 | — | — | US | claimed |
| EP-1799843-A4 | ASSAY FOR CYTOCHROME P450 ISOFORM 2C9 | MERCK & CO INC (US) | 2008-04-09 | — | — | EP | claimed |
| EP-1799843-A2 | ASSAY FOR CYTOCHROME P450 ISOFORM 2C9 | Merck & Co., Inc. (US) | 2007-06-27 | — | — | EP | claimed |
| WO-2006041844-A2 | ASSAY FOR CYTOCHROME P450 ISOFORM 2C9 | MERCK & CO., INC. (US) | 2006-04-20 | — | — | WO | claimed |
| EP-1429807-A2 | COMBINATION OF A NSAID AND A PDE-4 INHIBITOR | ALTANA Pharma AG (DE) | 2004-06-23 | — | — | EP | claimed |
| WO-2003024489-A2 | COMBINATION OF A NSAID AND A PDE-4 INHIBITOR | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | claimed |
| US-7629140-B2 | Assay for cytochrome P450 isoform 2C9 | ISTITUTO DI RICHERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2009-12-08 | — | — | US | disclosed |
| US-20080193950-A1 | Rapid and sensitive; radiometric; automatic; multiwell plates; incubating with tritium-labeled diclofenac | MERCK SHARP & DOHME CORP. | 2008-08-14 | — | — | US | disclosed |
| EP-1799843-A4 | ASSAY FOR CYTOCHROME P450 ISOFORM 2C9 | MERCK & CO INC (US) | 2008-04-09 | — | — | EP | disclosed |
| EP-1799843-A2 | ASSAY FOR CYTOCHROME P450 ISOFORM 2C9 | Merck & Co., Inc. (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006041844-A2 | ASSAY FOR CYTOCHROME P450 ISOFORM 2C9 | MERCK & CO., INC. (US) | 2006-04-20 | — | — | WO | disclosed |