Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.65 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7583347 | 0.81 | AKR1B1 (0.58) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL14861906 | 0.79 | ABCB11 (1.00) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL34411 | 0.79 | ABCB11 (1.00) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| SCHEMBL22654317 | 0.79 | ABCB11 (0.54) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| SCHEMBL4540934 | 0.78 | PTGS2 (0.61) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL57090 | 0.78 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL28429415 | 0.78 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL28895435 | 0.78 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL57092 | 0.78 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL28429368 | 0.78 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1429807-A2 | COMBINATION OF A NSAID AND A PDE-4 INHIBITOR | ALTANA Pharma AG (DE) | 2004-06-23 | — | — | EP | claimed |
| WO-2003024489-A2 | COMBINATION OF A NSAID AND A PDE-4 INHIBITOR | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | claimed |
| WO-2016069952-A1 | ANTI-ACNE COMPOSITION AND METHODS OF USE | RAYUDU SREEDHAR RAO (US) | 2016-05-06 | — | — | WO | disclosed |
| US-4683242-A | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-07-28 | — | — | US | disclosed |