Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 7/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541294 | 0.90 | PSEN1 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4542928 | 0.87 | LMNA (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4540868 | 0.82 | BDKRB1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8062136 | 0.82 | BDKRB1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8062139 | 0.81 | RAB9A (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4537833 | 0.81 | RAB9A (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4537242 | 0.80 | NPC1 (0.53) | BDKRB1EPHX2ALDH1A1 | |
| SCHEMBL4535199 | 0.80 | MMP1 (0.53) | BDKRB1PAX8HCRTR1HCRTR2 | |
| SCHEMBL4541024 | 0.80 | RAB9A (0.48) | LMNABDKRB1PAX8EPHX2 | |
| SCHEMBL4543050 | 0.79 | BDKRB1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |