Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | BMP1 | P13497 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 4/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.41 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 4/20 | 0.40 |
| ▸ | MMP9 | P14780 | 4/20 | 0.40 |
| ▸ | MMP14 | P50281 | 3/20 | 0.40 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.40 |
| ▸ | ADAM8 | P78325 | 2/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13923480 | 0.94 | BMP1 (0.44) | MMP13BMP1MMP1ADAM17ADAMTS4 | |
| SCHEMBL4371521 | 0.88 | UTS2R (0.41) | MMP13BMP1MMP1ADAM17ADAMTS4 | |
| SCHEMBL1800584 | 0.86 | ADAM17 (0.49) | BMP1MMP1ADAM17ADAMTS4ADAMTS1 | |
| SCHEMBL1802731 | 0.85 | ADAMTS7 (0.44) | MMP13MMP1ADAMTS7ADAMTS5 | |
| SCHEMBL1802730 | 0.85 | ADAMTS7 (0.44) | MMP13MMP1ADAMTS7ADAMTS5 | |
| SCHEMBL13923481 | 0.83 | MMP2 (0.49) | MMP13ADAMTS5MMP2MMP9 | |
| SCHEMBL13791856 | 0.83 | BMP1 (0.48) | BMP1MMP1ADAM17ADAMTS4ADAMTS1 | |
| SCHEMBL13923478 | 0.82 | LMNA (0.39) | BMP1MMP2MMP9 | |
| SCHEMBL1799334 | 0.78 | ADAM17 (0.50) | BMP1MMP1ADAM17ADAMTS4ADAMTS1 | |
| SCHEMBL14470899 | 0.78 | ADAM17 (0.50) | BMP1MMP1ADAM17ADAMTS4ADAMTS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |