SCHEMBL454552

SCHEMBL454552

O=C1c2cccc(Cl)c2C(=O)N1Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.41
KMT2A Q03164 3/20 0.41
MEN1 O00255 2/20 0.41
ALDH1A1 P00352 2/20 0.41
LMNA P02545 1/20 0.41
NSD2 O96028 2/20 0.40
CES1 P23141 3/20 0.39
BCHE P06276 1/20 0.37
DAO P14920 1/20 0.37
GRIA1 P42261 1/20 0.37
CACNG8 Q8WXS5 1/20 0.37
CYP1A2 P05177 1/20 0.37
POLB P06746 1/20 0.37
ERCC1 P07992 1/20 0.37
MAPT P10636 1/20 0.37
TSHR P16473 1/20 0.37
ALOX12 P18054 1/20 0.37
FEN1 P39748 1/20 0.37
ERCC4 Q92889 1/20 0.37
TDP1 Q9NUW8 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11214758 0.79 HSPA1A (0.55) KDM4EKMT2AMEN1ALDH1A1LMNA
SCHEMBL30725966 0.78 ALDH1A1 (0.56) KDM4EKMT2AMEN1ALDH1A1NSD2
SCHEMBL28289100 0.78 KDM4E (0.40) KDM4EKMT2AMEN1ALDH1A1LMNA
SCHEMBL9450349 0.78 KDM4E (0.43) KDM4EKMT2AMEN1ALDH1A1LMNA
SCHEMBL1500604 0.78 ALDH1A1 (0.56) KDM4EKMT2AMEN1ALDH1A1NSD2
SCHEMBL4407778 0.78 MAPT (0.56) KDM4EKMT2AMEN1ALDH1A1LMNA
SCHEMBL31405120 0.78 MAPT (0.56) KDM4EKMT2AMEN1ALDH1A1LMNA
SCHEMBL29556358 0.78 DPP4 (0.50) KMT2AMEN1ALDH1A1POLB
SCHEMBL1735119 0.76 MEN1 (0.58) KDM4EKMT2AMEN1ALDH1A1HPGD
SCHEMBL3684155 0.75 CES1 (0.37) KDM4EKMT2AMEN1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 165 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113637164-B Preparation method of amphiphilic biphenyl polyimide additive 哈尔滨工业大学(威海) 2023-05-23 CN claimed
CN-113549212-B Preparation method of functional polyetherimide additive 哈尔滨工业大学(威海) 2023-05-23 CN claimed
CN-113637164-A Preparation method of novel amphiphilic biphenyl polyimide additive 哈尔滨工业大学(威海) 2021-11-12 CN claimed
CN-113549212-A Novel preparation method of functional polyetherimide additive 哈尔滨工业大学(威海) 2021-10-26 CN claimed
EP-1235782-B1 METHOD FOR OXIDATION OF XYLENE DERIVATIVES GEN ELECTRIC (US) 2004-02-18 EP claimed
US-6465685-B1 SUCH AS CHLORO-O-XYLENE, ARE OXIDIZED IN A SOLVENT IN THE PRESENCE OF A METAL COMPOUND CATALYST WITH ADDITION OF PROMOTER AFTER THE REACTION HAS PROCEEDED TO AN INTERMEDIATE STAGE; PRODUCT COMPRISES CHLOROPHTHALIC ACID OR ANHYDRIDE GENERAL ELECTRIC COMPANY 2002-10-15 US claimed
EP-1235781-A1 METHOD FOR OXIDATION OF XYLENE DERIVATIVES GENERAL ELECTRIC COMPANY (US) 2002-09-04 EP claimed
EP-1235782-A1 METHOD FOR OXIDATION OF XYLENE DERIVATIVES GENERAL ELECTRIC COMPANY (US) 2002-09-04 EP claimed
US-6399790-B1 USING METAL CATALYST GENERAL ELECTRIC COMPANY 2002-06-04 US claimed
WO-2001038282-A1 METHOD FOR OXIDATION OF XYLENE DERIVATIVES GENERAL ELECTRIC COMPANY (US) 2001-05-31 WO claimed
WO-2001038281-A1 METHOD FOR OXIDATION OF XYLENE DERIVATIVES GENERAL ELECTRIC COMPANY (US) 2001-05-31 WO claimed
WO-2025228547-A1 PROCESSES FOR PREPARING PHENETHYLAMINE COMPOUNDS CYBIN IRL LIMITED (IE) 2025-11-06 WO disclosed
EP-3137551-B1 FIBER REINFORCED POLYETHERIMIDE COMPOSITIONS SHPP GLOBAL TECH BV (NL) 2024-08-07 EP disclosed
US-11926733-B2 Polycarbonate copolymer blends, articles formed therefrom, and methods of manufacture SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2024-03-12 US disclosed
CN-113563153-B Method for preparing monochloro-ortho-xylene by continuous chlorination of ortho-xylene 中化学科学技术研究有限公司 2024-01-23 CN disclosed
US-5668201-A Flame retardant graft copolymer composition GENERAL ELECTRIC COMPANY (US) 1997-09-16 US disclosed
US-5266679-A Heck carbonylation reaction, carbon monoxide EASTMAN KODAK COMPANY (US) 1993-11-30 US disclosed
EP-0530706-A1 A method for producing polyamide-imides EASTMAN KODAK COMPANY (US) 1993-03-10 EP disclosed
EP-0219014-A2 Flame retardant elastomeric compositions GENERAL ELECTRIC COMPANY (US) 1987-04-22 EP disclosed
US-4639486-A POLYETHERIMIDE ESTER AND HALOGENATED MATERIAL GENERAL ELECTRIC COMPANY (US) 1987-01-27 US disclosed