Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 9/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20043209 | 0.93 | PDE10A (0.41) | PDE10ASCN10AKCNH2METAP2TSHR | |
| SCHEMBL20047407 | 0.88 | PDE10A (0.39) | PDE10ASCN10AKCNH2METAP2TRPV1 | |
| SCHEMBL12173605 | 0.86 | KIF11 (0.42) | PDE10ATSHRTRPV1ALDH1A1HPGD | |
| SCHEMBL23502522 | 0.85 | MAPK1 (0.36) | PDE10ASCN10AALDH1A1NPC1RAB9A | |
| SCHEMBL10220534 | 0.83 | NQO2 (0.48) | ALDH1A1TDP1NPC1RAB9AKDM4E | |
| SCHEMBL21161268 | 0.82 | PDE10A (0.38) | PDE10ASCN10AKCNH2METAP2TRPV1 | |
| SCHEMBL16232299 | 0.81 | PDE10A (0.41) | PDE10ASCN10AKCNH2METAP2TSHR | |
| SCHEMBL21161311 | 0.80 | PDE10A (0.32) | PDE10ASCN10A | |
| SCHEMBL12755253 | 0.80 | PDE10A (0.40) | PDE10ASCN10AKCNH2METAP2TRPV1 | |
| SCHEMBL3662373 | 0.80 | ALDH1A1 (0.52) | PDE10ASCN10AKCNH2METAP2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230141569-A1 | FLUORESCENT DYE, AND PREPARATION METHOD AND USES THEREOF | FLUORESCENCE DIAGNOSIS (SHANGHAI) BIOTECH COMPANY LTD. (CN) | 2023-05-11 | — | — | US | disclosed |
| US-11034684-B2 | Isoxazole analogs as FXR agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2021-06-15 | — | — | US | disclosed |
| US-20200248069-A1 | FLUORESCENT PROBE, PREPARATION METHOD THEREFOR AND USE THEREOF | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2020-08-06 | — | — | US | disclosed |
| US-10689391-B2 | Isoxazole analogs as FXR agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2020-06-23 | — | — | US | disclosed |
| US-10450306-B2 | Isoxazole analogs as FXR agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2019-10-22 | — | — | US | disclosed |
| US-20190194216-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2019-06-27 | — | — | US | disclosed |
| US-20180099957-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2018-04-12 | — | — | US | disclosed |
| US-20180099957-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2018-04-12 | — | — | US | disclosed |
| US-8178557-B2 | Compounds and methods of use | AMGEN INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20090176774-A1 | Compounds and methods of use | AMGEN INC. (US) | 2009-07-09 | — | — | US | disclosed |
| US-7435823-B2 | Compounds and methods of use | AMGEN INC. (US) | 2008-10-14 | — | — | US | disclosed |
| US-20080132503-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10450306-B2 | Isoxazole analogs as FXR agonists and methods of use thereof | GPBAR1, SLC10A1, NR1H4 | PDE10A 1004/4885SCN10A 3305/4885KCNH2 4528/4885 |
| US-20180099957-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | GPBAR1, SLC10A1, NR1H4 | PDE10A 1004/4885SCN10A 3305/4885KCNH2 4528/4885 |
| US-20230141569-A1 | FLUORESCENT DYE, AND PREPARATION METHOD AND USES THEREOF | DNASE1, DNA2, RNGTT | PDE10A 3329/4885SCN10A 4483/4885KCNH2 4604/4885 |
| US-20190194216-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | SLC10A1, NR1H4, GPBAR1 | PDE10A 801/4885SCN10A 2962/4885KCNH2 4411/4885 |
| US-20200248069-A1 | FLUORESCENT PROBE, PREPARATION METHOD THEREFOR AND USE THEREOF | WASF2, FAM162A, HASPIN | PDE10A 3370/4885SCN10A 4548/4885KCNH2 4507/4885 |
| US-20090176774-A1 | Compounds and methods of use | HGF, HGFAC, MET | PDE10A 2396/4885SCN10A 4439/4885KCNH2 4774/4885 |
| US-11034684-B2 | Isoxazole analogs as FXR agonists and methods of use thereof | GPBAR1, SLC10A1, NR1H4 | PDE10A 1004/4885SCN10A 3305/4885KCNH2 4528/4885 |
| US-10689391-B2 | Isoxazole analogs as FXR agonists and methods of use thereof | SLC10A1, NR1H4, GPBAR1 | PDE10A 801/4885SCN10A 2962/4885KCNH2 4411/4885 |
| US-20080132503-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC3 | PDE10A 4038/4885SCN10A 3950/4885KCNH2 4025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.