Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RBP4 | P02753 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22721931 | 0.85 | ALDH1A1 (0.60) | ALDH1A1POLBGAASMN1; SMN2LMNA | |
| SCHEMBL11069252 | 0.84 | ALDH1A1 (0.50) | ALDH1A1POLBMAPK1HPGDAKR1C3 | |
| SCHEMBL11069275 | 0.84 | ALDH1A1 (0.50) | ALDH1A1POLBMAPK1HPGDAKR1C3 | |
| SCHEMBL31753773 | 0.79 | ALDH1A1 (0.50) | ALDH1A1POLBMAPK1HPGDAKR1C3 | |
| SCHEMBL8172740 | 0.78 | ALDH1A1 (0.53) | ALDH1A1POLBMAPK1HPGDGAA | |
| SCHEMBL714234 | 0.77 | SMN1; SMN2 (0.66) | ALDH1A1HPGDGAASMN1; SMN2LMNA | |
| SCHEMBL714235 | 0.77 | SMN1; SMN2 (0.66) | ALDH1A1HPGDGAASMN1; SMN2LMNA | |
| SCHEMBL29665643 | 0.77 | SMN1; SMN2 (0.66) | ALDH1A1HPGDGAASMN1; SMN2LMNA | |
| SCHEMBL11141439 | 0.76 | ALDH1A1 (0.55) | ALDH1A1POLBGAASMN1; SMN2LMNA | |
| SCHEMBL9073576 | 0.76 | ALDH1A1 (0.55) | ALDH1A1POLBGAASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118891261-A | Covalent EGFR inhibitors and methods of use thereof | 丹娜-法伯癌症研究院 | 2024-11-01 | — | — | CN | disclosed |
| CN-104379146-B | Inhibit the composition and method of varial polymerases | 拜奥克里斯特制药公司 | 2018-07-10 | — | — | CN | disclosed |
| CN-106573073-A | FAP-activated therapeutics and uses related thereto | 塔夫茨大学信托人 | 2017-04-19 | — | — | CN | disclosed |
| CN-104379146-A | Compositions and methods for inhibiting viral polymerase | BIOCRYST PHARM INC | 2015-02-25 | — | — | CN | disclosed |
| CN-102781236-B | Amino acid conjugates of quetiapine, methods of making and using the same | KEMPHARM INC | 2015-01-07 | — | — | CN | disclosed |
| CN-102781236-A | Amino acid conjugates of quetiapine, methods of making and using the same | KEMPHARM INC | 2012-11-14 | — | — | CN | disclosed |
| EP-2036918-A1 | PEPTIDE DERIVATIVE | Vexon, Inc. (JP) | 2009-03-18 | — | — | EP | disclosed |
| EP-0961779-A1 | SUBSTITUTED AMINO BICYCLIC-$g(b)-LACTAM PENAM AND CEPHAM DERIVATIVES AS CYSTEINE PROTEASE INHIBITORS | SYNPHAR LABORATORIES INC. (CA) | 1999-12-08 | — | — | EP | disclosed |
| WO-1998032766-A1 | SUBSTITUTED AMINO BICYCLIC-β-LACTAM PENAM AND CEPHAM DERIVATIVES AS CYSTEINE PROTEASE INHIBITORS | SYNPHAR LABORATORIES INC. (US) | 1998-07-30 | — | — | WO | disclosed |