Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.33 |
| ▸ | FEN1 | P39748 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3978560 | 0.83 | RXRA (0.42) | MAPT | |
| SCHEMBL3972380 | 0.83 | SLC6A2 (0.39) | SLC6A2SLC6A4JAK2SLC6A3HTR6 | |
| SCHEMBL3973958 | 0.82 | SSTR5 (0.40) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4704418 | 0.79 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL3979077 | 0.77 | SSTR5 (0.40) | KCNH2 | |
| SCHEMBL3970171 | 0.77 | HTR2A (0.36) | SLC6A2SLC6A4SLC6A3KCNH2ALDH1A1 | |
| SCHEMBL3971706 | 0.76 | SLC6A2 (0.35) | SLC6A2SLC6A4JAK2SLC6A3KCNH2 | |
| SCHEMBL3970388 | 0.75 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL3972445 | 0.75 | SSTR5 (0.40) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL3979779 | 0.74 | RXRA (0.41) | SLC6A2SLC6A4SLC6A3KCNH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |